PlAsmA chemerin is A strong AnD inDePenDent PreDictor of cArDiovAsculAr event risk
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چکیده
results: At baseline, plasma chemerin was significantly higher in patients with the MetS as defined by the current harmonized consensus definition (n=147) than in non-MetS subjects (201±71 ng/ml versus 163±62 ng/ml p<0.001) and was inversely correlated with estimated glomerular filtration rate (eGFR; r=-0.33, p<0.001). During follow-up, chemerin significantly predicted cardiovascular events (n=82) univariately, after adjustment for age, gender, body mass index, and eGFR, and also after additional adjustment for the presence of significant baseline CAD, with standardized hazard ratios of 1.83 [1.19-2.83], p=0.006; 1.77 [1.12-2.80], p=0.015; and 1.69 [1.07-2.67], p=0.024, respectively.
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